Table 2 Intervention and patient characteristics
Study | Country | Start-end date | Total N (I/C)a | % with prior HCV therapy | % with concomitant HCV therapy | Age (years) | Male % | Baseline liver damage (%) | Current or past substance abuse (%) |
|---|---|---|---|---|---|---|---|---|---|
Bruno (2007) [34] | Italy | 1999-2004 | 53 (29/24) | NR | NR | median 37.1 | 90 | 100 compensated cirrhosis | NR |
Giron-Gonzalez (2007) [29] | Spain | 2004-2006 | 92 (76/22) | 19 | 8 | median 40 | 89 | 100 compensated cirrhosis | Alcohol: 46 current IDU: 90 |
Limketkai (2012) [23] | USA | 1993-2011 | 638 (440/198) | NR | NR | median 45.6 | 66 | METAVIR F0-F2: 82 F3: 6 F4: 1 | Alcohol: 47 current IDU: 76 past |
Macias (2009) [24] | Spain | 1986-2008 | 135 (113/22) | NR | 44 | mean 37 | 68 | Scheuer F0-F2: 78 F3: 22 F4: 0 | Alcohol: 21 current IDU: 90 |
Macias (2006) [25] | Spain | 1991-2005 | 683 (509/174) | NR | 0 | median 23c | 83 | Scheuer F0-F2: 68 F3: 18 F4: 14 | Alcohol: 23 current IDU: 86 current |
Mariné-Barjoan (2004) [35] | France | 1997-2000 | 116 (91/25) | 0 | 0 | median 21c | 67 | METAVIR F0-F2: 74 F3-4: 26 | Alcohol: 14 current IDU: 72 |
Mehta (2005) [30] | USA | 2001-NRb | 210 (135/75) | 0 | NR | median 44.5 | 67 | Ishak F0-F2: 74 ≥F3:26 | Alcohol: 39.5 history IDU: 77 current or past |
Merchante (2006) [31] | Spain | 1997-2004 | 153 (101/58) | 6 | NR | median 38 | 86 | 100 compensated cirrhosis | Alcohol: 46 current IDU: 88 previous |
Pineda (2009) [32] | Spain | 1996-2006 | 154 (145/9) | NR | 43 | median 39.9 | 87 | 100 compensated cirrhosis | Alcohol: 21 IDU: 86 current or previous |
Qurishi (2003) [26] | Germany | 1990-2002 | 285 (148/137) | NR | 0 | median 30 | 95 | No symptomatic liver disease | Alcohol: 12 IDU: 15 |
Ragni (2009) [27] | USA | 1970-2005 | 85 (60/25) | NR | 1 | mean 39d | 100 | No cirrhosis | Alcohol: 12 IDU: NR |
Reiberger (2010) [36] | Austria | NR-NR | 74 (49/25) | 0 | 0 | mean 37 | 77 | METAVIR F0-F2: 59 F3-F4: 41 | Alcohol: 29 current IDU: NR |
Sanmartin (2014) [33] | Spain | 1997-2010 | 162 (149/13) | 0 | 54 | mean 37 | 73 | Scheuer F0-F2: 100 | Alcohol & IDU: 0 current |
Schiavini (2006) [28] | Italy | 1985-2002 | 36 (20/16) | NR | 92 | median 28 | 75 | Ishak-Knodell F0-2: 75 F3-4: 25 | Alcohol: 53 history IDU: NR |