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Table 2 Intervention and patient characteristics

From: Antiretroviral therapy and liver disease progression in HIV and hepatitis C co-infected patients: a systematic review and meta-analysis

Study Country Start-end date Total N (I/C)a % with prior HCV therapy % with concomitant HCV therapy Age (years) Male % Baseline liver damage (%) Current or past substance abuse (%)
Bruno (2007) [34] Italy 1999-2004 53 (29/24) NR NR median 37.1 90 100 compensated cirrhosis NR
Giron-Gonzalez (2007) [29] Spain 2004-2006 92 (76/22) 19 8 median 40 89 100 compensated cirrhosis Alcohol: 46 current
IDU: 90
Limketkai (2012) [23] USA 1993-2011 638 (440/198) NR NR median 45.6 66 METAVIR F0-F2: 82
F3: 6
F4: 1
Alcohol: 47 current
IDU: 76 past
Macias (2009) [24] Spain 1986-2008 135 (113/22) NR 44 mean 37 68 Scheuer
F0-F2: 78
F3: 22
F4: 0
Alcohol: 21 current
IDU: 90
Macias (2006) [25] Spain 1991-2005 683 (509/174) NR 0 median 23c 83 Scheuer
F0-F2: 68
F3: 18
F4: 14
Alcohol: 23 current
IDU: 86 current
Mariné-Barjoan (2004) [35] France 1997-2000 116 (91/25) 0 0 median 21c 67 METAVIR F0-F2: 74
F3-4: 26
Alcohol: 14 current
IDU: 72
Mehta (2005) [30] USA 2001-NRb 210 (135/75) 0 NR median 44.5 67 Ishak
F0-F2: 74
≥F3:26
Alcohol: 39.5 history
IDU: 77 current or past
Merchante (2006) [31] Spain 1997-2004 153 (101/58) 6 NR median 38 86 100 compensated cirrhosis Alcohol: 46 current
IDU: 88 previous
Pineda (2009) [32] Spain 1996-2006 154 (145/9) NR 43 median 39.9 87 100 compensated cirrhosis Alcohol: 21
IDU: 86 current or previous
Qurishi (2003) [26] Germany 1990-2002 285 (148/137) NR 0 median 30 95 No symptomatic liver disease Alcohol: 12
IDU: 15
Ragni (2009) [27] USA 1970-2005 85 (60/25) NR 1 mean 39d 100 No cirrhosis Alcohol: 12
IDU: NR
Reiberger (2010) [36] Austria NR-NR 74 (49/25) 0 0 mean 37 77 METAVIR F0-F2: 59
F3-F4: 41
Alcohol: 29 current
IDU: NR
Sanmartin (2014) [33] Spain 1997-2010 162 (149/13) 0 54 mean 37 73 Scheuer
F0-F2: 100
Alcohol & IDU: 0 current
Schiavini (2006) [28] Italy 1985-2002 36 (20/16) NR 92 median 28 75 Ishak-Knodell
F0-2: 75
F3-4: 25
Alcohol: 53 history
IDU: NR
  1. ART: 0.279 (0 · 122–0 · 414); untreated: 0.255 (0 · 079–0 · 473); untreated: 145 (SD 43, range 2–610) (time of measurement UC)
  2. aI = Intervention, C = Control
  3. bMedian follow-up 5 years (IQR 2.9-7.5)
  4. cAt HCV infection
  5. dAt follow-up